Interferon-a/b Receptor as a Prognostic Marker in Osteosarcoma
نویسندگان
چکیده
Background: A large-scale randomized trial of adjuvant interferon-a therapy for patients with osteosarcoma has been initiated as a joint protocol by the European and American Osteosarcoma Study Group. Because the expression of functional interferon-a/b receptor is necessary for interferon-a agents to interact with osteosarcoma cells, we examined the expression of interferon-a/b receptor in a series of osteosarcoma specimens.
منابع مشابه
Expression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker
Osteosarcoma is the most frequent malignant bone tumor with a peak incidence in the second and third decades of life. Diagnosis of patients with osteosarcoma is limited to clinico-pathological parameters whereas molecular markers of tumor initiation and promotion have not yet been identified. We aimed to study the expression of the anti-apoptotic survivin gene in osteosarcoma specimens. A total...
متن کاملبررسی فراوانی حضور مارکر ایمونوهیستوشیمی فروپورتین در نمونههای بهدستآمده از بافت سرطانی بیماران مبتلا به سرطان پستان و ارتباط آن با فاکتورهای پروگنوستیک
Background & Aims: Breast cancer is the most prevalent malignancy in women. A few articles describe a marked decrease in the levels of ferroportin in breast cancer cells.The presented results demonstrate convincingly the incredible diagnostic and prognostic value of ferroportin expression in breast cancer and suggest that determination of this molecular marker maybe used as guidance toward ind...
متن کاملprognostic importance of the pathologic fracture and surgical options in osteosarcoma: a retrospective clinical study
Background & Aims: Osteosarcoma is one of the most prevalent malignant bone tumors . This study is designed to assess the prognostic effect of pathologic fracture and treatment options on survival of patients with osteosarcoma. Materials & Methods: In this study, prognosis of 106 patients with limb osteosarcoma, which were treated at three hospitals in Tehran from April to August 2012 ...
متن کاملAndrogen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11
Osteosarcoma is the most common bone cancer in children and adolescents. Previously, we have found that cyclin-dependent kinase 11 (CDK11) signaling was essential for osteosarcoma cell growth and survival. Subsequently, CDK11 siRNA gene targeting, expression profiling, and network reconstruction of differentially expressed genes were performed between CDK11 knock down and wild type osteosarcoma...
متن کاملSerum miRNA-34a serves as a diagnostic and prognostic bio-marker in osteosarcoma
Background: MicroRNA-34a (miR-34a) had been reported to be decreased in osteosarcoma, but its effects on diagnosis and prognosis were still unclear. The purpose of this study was to investigate the expression and clinical significance of miR-34a in osteosarcoma. Methods: The expression of miR-34a in tissues and serum of all patients and controls was detected by quantitative real-time polymerase...
متن کامل